Statistics on dSysMap (ver. 2017_06)

Diseases
Phenotypes 3516
Diseases (clusters of phenotypes) 1275
Phenotypes/disease 2.8
Phenotypes with muts. on structures 2292
Diseases with muts. on structures 994
Proteins
Proteins in the human proteome 20314
Proteins affected by disease mutations 2606
Mutated proteins with structural data 2018
  - Mutated proteins with complete structures 417
  - Mutated proteins with complete models 428
  - Mutated proteins with partial struct/models 1173
Mutated proteins w/o structural data 588
Mutated proteins in the interactome 2171
Mut. proteins with struct. data in the interactome 1795
Proteins affected by interaction mutations 633
Mutations
Mutations (in total) 28399
Mutations/phenotype 8.1
Mutations/disease 22.3
Structurally classified mutations 18141
  - Surface mutations 12508
  - Buried mutations 5633
  - Interface mutations 3503
Mutations w/o struct. classification 10258
Interactions
Interactions in the human binary interactome 95152
Interactions affected by disease mutations 1557
Interactions with structural data 11735
  - Interactions with exp. structures 5757
  - Interactions with global models 4293
  - Interactions with domain-domain models 1685
Interactions w/o structural data 83417
Mutations in predicted disordered regions (*)
Proteins with disordered fragments (at least 30 res) 15577 (out of 20341, 77%)
Disordered residues (at least 30 res) 4068081 (out of 11371216, 36%)
Proteins with >20% of interf disordered 1583 (out of 4847 prots with known interf., 33%)
Interactions with >20% of interf disordered 2993 (out of 7737 ints with known interf., 39%)
Mutations in a disordered fragment (at least 30 res) 3558 (out of 23912 total mutations, 15%)
Mutations in a disordered residue at an interface (at least 30 res) 312 (out of 3558 mutations in a disordered fragment, 9%)

(*) Disordered regions were predicted with VSL2B.

Representation of MeSH categories
Category Number of disease phenotypes Number of OMIM phenotypes
In dSysMap Total % in dSysMap In dSysMap Total % in dSysMap
Animal disease 0 136 0% 0 0 100%
Bacterial infection or mycosis 10 419 2% 10 27 37%
Blood disease 153 587 26% 153 223 69%
Cancer 102 1106 9% 102 225 45%
Cardiovascular disease 188 1003 19% 188 320 59%
Congenital abnormality 576 2705 21% 576 944 61%
Connective tissue disease 65 250 26% 65 94 69%
Digestive system disease 83 627 13% 83 171 49%
Ear-nose-throat disease 121 583 21% 121 243 50%
Endocrine system disease 147 700 21% 147 269 55%
Environmental origin disorders 0 5 0% 0 0 100%
Eye disease 262 1267 21% 262 483 54%
Fetal disease 5 51 10% 5 12 42%
Genetic disease 1056 3087 34% 1056 1558 68%
Immune system disease 83 548 15% 83 195 43%
Infant-newborn disease 60 217 28% 60 82 73%
Lymphatic disease 27 214 13% 27 57 47%
Mental disorder 82 761 11% 82 208 39%
Metabolic disease 501 1387 36% 501 665 75%
Mouth disease 54 586 9% 54 115 47%
Musculoskeletal disease 471 2277 21% 471 732 64%
Nervous system disease 749 3475 22% 749 1302 58%
Nutrition disorder 20 119 17% 20 45 44%
Occupational disease 1 28 4% 1 1 100%
Parasitic disease 0 161 0% 0 5 0%
Pathology 133 1430 9% 133 254 52%
Pregnancy complication 9 154 6% 9 18 50%
Respiratory tract disease 44 419 11% 44 87 51%
Signs and symptoms 265 1566 17% 265 507 52%
Skin disease 203 1152 18% 203 360 56%
Substance-related disorder 0 39 0% 0 5 0%
Urogenital disease 173 807 21% 173 270 64%
Viral disease 3 252 1% 3 16 19%
Wounds and injuries 3 245 1% 3 6 50%

The data in the current version of dSysMap is based on the contents of the following databases:

Database Version
UniprotKB 2017_06
Pfam 30.0
3did 2017_06
BINDTranslation 1.0
BioGRID 3.4.149
Database Version
DIP 05/02/2017
HPRD 041310
InnateDB 27/10/2015
IntAct 03/06/2017
PDB 2017_06