Statistics on dSysMap (ver. 2018_04)

Diseases
Phenotypes 3610
Diseases (clusters of phenotypes) 1303
Phenotypes/disease 2.8
Phenotypes with muts. on structures 2382
Diseases with muts. on structures 1025
Proteins
Proteins in the human proteome 20462
Proteins affected by disease mutations 2701
Mutated proteins with structural data 2100
  - Mutated proteins with complete structures 474
  - Mutated proteins with complete models 419
  - Mutated proteins with partial struct/models 1207
Mutated proteins w/o structural data 601
Mutated proteins in the interactome 2283
Mut. proteins with struct. data in the interactome 1893
Proteins affected by interaction mutations 714
Mutations
Mutations (in total) 29006
Mutations/phenotype 8.0
Mutations/disease 22.3
Structurally classified mutations 18819
  - Surface mutations 13060
  - Buried mutations 5759
  - Interface mutations 3823
Mutations w/o struct. classification 10187
Interactions
Interactions in the human binary interactome 98081
Interactions affected by disease mutations 1754
Interactions with structural data 12750
  - Interactions with exp. structures 6422
  - Interactions with global models 4549
  - Interactions with domain-domain models 1779
Interactions w/o structural data 85331
Mutations in predicted disordered regions (*)
Proteins with disordered fragments (at least 30 res) 15577 (out of 20341, 77%)
Disordered residues (at least 30 res) 4068081 (out of 11371216, 36%)
Proteins with >20% of interf disordered 1583 (out of 4847 prots with known interf., 33%)
Interactions with >20% of interf disordered 2993 (out of 7737 ints with known interf., 39%)
Mutations in a disordered fragment (at least 30 res) 3558 (out of 23912 total mutations, 15%)
Mutations in a disordered residue at an interface (at least 30 res) 312 (out of 3558 mutations in a disordered fragment, 9%)

(*) Disordered regions were predicted with VSL2B.

Representation of MeSH categories
Category Number of disease phenotypes Number of OMIM phenotypes
In dSysMap Total % in dSysMap In dSysMap Total % in dSysMap
Animal disease 0 136 0% 0 0 100%
Bacterial infection or mycosis 14 439 3% 14 37 38%
Blood disease 204 636 32% 204 297 69%
Blunt Head Injuries 0 1 0% 0 0 100%
Blunt Head Injury 0 1 0% 0 0 100%
Cancer 132 1138 12% 132 260 51%
Cardiovascular disease 274 1100 25% 274 427 64%
Closed Head Injuries 0 1 0% 0 0 100%
Closed Head Injury 0 1 0% 0 0 100%
Closed Head Trauma 0 1 0% 0 0 100%
Closed Head Traumas 0 1 0% 0 0 100%
Congenital abnormality 878 3009 29% 878 1365 64%
Connective tissue disease 89 274 32% 89 121 74%
Digestive system disease 108 649 17% 108 202 53%
Ear-nose-throat disease 171 648 26% 171 329 52%
Endocrine system disease 214 751 28% 214 342 63%
Environmental origin disorders 0 5 0% 0 0 100%
Eye disease 403 1401 29% 403 672 60%
Fetal disease 11 53 21% 11 18 61%
Genetic disease 1445 3510 41% 1445 2089 69%
Head Injuries, Blunt 0 1 0% 0 0 100%
Head Injuries, Nonpenetrating 0 1 0% 0 0 100%
Head Injury, Blunt 0 1 0% 0 0 100%
Head Injury, Closed 0 1 0% 0 0 100%
Head Injury, Nonpenetrating 0 1 0% 0 0 100%
Head Trauma, Closed 0 1 0% 0 0 100%
Head Traumas, Closed 0 1 0% 0 0 100%
Immune system disease 132 625 21% 132 275 48%
Infant-newborn disease 69 228 30% 69 95 73%
Injuries, Closed Head 0 1 0% 0 0 100%
Lymphatic disease 34 226 15% 34 69 49%
Mental disorder 195 900 22% 195 379 51%
Metabolic disease 698 1585 44% 698 918 76%
Mouth disease 91 606 15% 91 161 57%
Musculoskeletal disease 661 2461 27% 661 996 66%
Nervous system disease 1186 3923 30% 1186 1904 62%
Nonpenetrating Head Injuries 0 1 0% 0 0 100%
Nonpenetrating Head Injury 0 1 0% 0 0 100%
Nutrition disorder 25 124 20% 25 54 46%
Occupational disease 1 29 3% 1 2 50%
Parasitic disease 0 159 0% 0 5 0%
Pathology 233 1575 15% 233 402 58%
Pregnancy complication 17 161 11% 17 29 59%
Respiratory tract disease 70 458 15% 70 131 53%
Signs and symptoms 468 1852 25% 468 819 57%
Skin disease 293 1239 24% 293 477 61%
Substance-related disorder 1 43 2% 1 6 17%
Urogenital disease 236 875 27% 236 359 66%
Viral disease 3 254 1% 3 18 17%
Wounds and injuries 6 275 2% 6 14 43%

The data in the current version of dSysMap is based on the contents of the following databases:

Database Version
UniprotKB 2018_04
Pfam 30.0
3did 2018_04
BINDTranslation 1.0
BioGRID 3.4.160
Database Version
DIP 05/02/2017
HPRD 041310
InnateDB 27/10/2015
IntAct 21/03/2018
PDB 2018_04