Statistics on dSysMap (ver. 2016_06)

Diseases
Phenotypes 3270
Diseases (clusters of phenotypes) 1255
Phenotypes/disease 2.6
Phenotypes with muts. on structures 2105
Diseases with muts. on structures 973
Proteins
Proteins in the human proteome 20298
Proteins affected by disease mutations 2423
Mutated proteins with structural data 1861
  - Mutated proteins with complete structures 371
  - Mutated proteins with complete models 403
  - Mutated proteins with partial struct/models 1087
Mutated proteins w/o structural data 562
Mutated proteins in the interactome 1912
Mut. proteins with struct. data in the interactome 1587
Proteins affected by interaction mutations 554
Mutations
Mutations (in total) 27062
Mutations/phenotype 8.3
Mutations/disease 21.6
Structurally classified mutations 16841
  - Surface mutations 11574
  - Buried mutations 5267
  - Interface mutations 2996
Mutations w/o struct. classification 10221
Interactions
Interactions in the human binary interactome 66452
Interactions affected by disease mutations 1146
Interactions with structural data 9875
  - Interactions with exp. structures 5235
  - Interactions with global models 3254
  - Interactions with domain-domain models 1386
Interactions w/o structural data 56577
Mutations in predicted disordered regions (*)
Proteins with disordered fragments (at least 30 res) 15577 (out of 20341, 77%)
Disordered residues (at least 30 res) 4068081 (out of 11371216, 36%)
Proteins with >20% of interf disordered 1583 (out of 4847 prots with known interf., 33%)
Interactions with >20% of interf disordered 2993 (out of 7737 ints with known interf., 39%)
Mutations in a disordered fragment (at least 30 res) 3558 (out of 23912 total mutations, 15%)
Mutations in a disordered residue at an interface (at least 30 res) 312 (out of 3558 mutations in a disordered fragment, 9%)

(*) Disordered regions were predicted with VSL2B.

Representation of MeSH categories
Category Number of disease phenotypes Number of OMIM phenotypes
In dSysMap Total % in dSysMap In dSysMap Total % in dSysMap
Animal disease 0 136 0% 0 0 100%
Bacterial infection or mycosis 10 419 2% 10 27 37%
Blood disease 151 588 26% 151 223 68%
Cancer 100 1107 9% 100 225 44%
Cardiovascular disease 194 1008 19% 194 324 60%
Congenital abnormality 582 2716 21% 582 952 61%
Connective tissue disease 64 251 25% 64 94 68%
Digestive system disease 83 627 13% 83 171 49%
Ear-nose-throat disease 118 583 20% 118 243 49%
Endocrine system disease 148 702 21% 148 269 55%
Environmental origin disorders 0 5 0% 0 0 100%
Eye disease 263 1267 21% 263 483 54%
Fetal disease 5 51 10% 5 12 42%
Genetic disease 1058 3093 34% 1058 1563 68%
Immune system disease 81 550 15% 81 196 41%
Infant-newborn disease 58 217 27% 58 82 71%
Lymphatic disease 28 214 13% 28 58 48%
Mental disorder 79 764 10% 79 211 37%
Metabolic disease 498 1386 36% 498 664 75%
Mouth disease 53 586 9% 53 115 46%
Musculoskeletal disease 472 2281 21% 472 735 64%
Nervous system disease 744 3479 21% 744 1308 57%
Nutrition disorder 20 118 17% 20 44 45%
Occupational disease 1 28 4% 1 1 100%
Parasitic disease 0 161 0% 0 5 0%
Pathology 130 1432 9% 130 255 51%
Pregnancy complication 9 154 6% 9 18 50%
Respiratory tract disease 43 419 10% 43 87 49%
Signs and symptoms 261 1569 17% 261 511 51%
Skin disease 202 1156 17% 202 362 56%
Substance-related disorder 0 39 0% 0 5 0%
Urogenital disease 174 811 21% 174 273 64%
Viral disease 3 252 1% 3 16 19%
Wounds and injuries 3 245 1% 3 6 50%

The data in the current version of dSysMap is based on the contents of the following databases:

Database Version
UniprotKB 2016_06
Pfam 27.0
3did 2016_06
BINDTranslation 1.0
BioGRID 3.4.137
Database Version
DIP 30/04/2016
HPRD 041310
InnateDB 27/10/2015
IntAct 08/04/2016
PDB 2016_06