Statistics on dSysMap (ver. 2017_01)

Diseases
Phenotypes 3425
Diseases (clusters of phenotypes) 1255
Phenotypes/disease 2.7
Phenotypes with muts. on structures 2228
Diseases with muts. on structures 980
Proteins
Proteins in the human proteome 20268
Proteins affected by disease mutations 2534
Mutated proteins with structural data 1961
  - Mutated proteins with complete structures 399
  - Mutated proteins with complete models 418
  - Mutated proteins with partial struct/models 1144
Mutated proteins w/o structural data 573
Mutated proteins in the interactome 2100
Mut. proteins with struct. data in the interactome 1739
Proteins affected by interaction mutations 619
Mutations
Mutations (in total) 27863
Mutations/phenotype 8.1
Mutations/disease 22.2
Structurally classified mutations 17613
  - Surface mutations 12066
  - Buried mutations 5547
  - Interface mutations 3320
Mutations w/o struct. classification 10250
Interactions
Interactions in the human binary interactome 92824
Interactions affected by disease mutations 1523
Interactions with structural data 11314
  - Interactions with exp. structures 5546
  - Interactions with global models 4096
  - Interactions with domain-domain models 1672
Interactions w/o structural data 81510
Mutations in predicted disordered regions (*)
Proteins with disordered fragments (at least 30 res) 15577 (out of 20341, 77%)
Disordered residues (at least 30 res) 4068081 (out of 11371216, 36%)
Proteins with >20% of interf disordered 1583 (out of 4847 prots with known interf., 33%)
Interactions with >20% of interf disordered 2993 (out of 7737 ints with known interf., 39%)
Mutations in a disordered fragment (at least 30 res) 3558 (out of 23912 total mutations, 15%)
Mutations in a disordered residue at an interface (at least 30 res) 312 (out of 3558 mutations in a disordered fragment, 9%)

(*) Disordered regions were predicted with VSL2B.

Representation of MeSH categories
Category Number of disease phenotypes Number of OMIM phenotypes
In dSysMap Total % in dSysMap In dSysMap Total % in dSysMap
Animal disease 0 136 0% 0 0 100%
Bacterial infection or mycosis 10 419 2% 10 27 37%
Blood disease 152 588 26% 152 223 68%
Cancer 102 1107 9% 102 225 45%
Cardiovascular disease 193 1008 19% 193 324 60%
Congenital abnormality 587 2716 22% 587 952 62%
Connective tissue disease 65 251 26% 65 94 69%
Digestive system disease 82 627 13% 82 171 48%
Ear-nose-throat disease 120 583 21% 120 243 49%
Endocrine system disease 148 702 21% 148 269 55%
Environmental origin disorders 0 5 0% 0 0 100%
Eye disease 266 1267 21% 266 483 55%
Fetal disease 5 51 10% 5 12 42%
Genetic disease 1066 3094 34% 1066 1564 68%
Immune system disease 80 550 15% 80 196 41%
Infant-newborn disease 58 217 27% 58 82 71%
Lymphatic disease 28 214 13% 28 58 48%
Mental disorder 81 765 11% 81 211 38%
Metabolic disease 499 1387 36% 499 665 75%
Mouth disease 54 586 9% 54 115 47%
Musculoskeletal disease 474 2281 21% 474 735 64%
Nervous system disease 752 3480 22% 752 1308 57%
Nutrition disorder 20 118 17% 20 44 45%
Occupational disease 1 28 4% 1 1 100%
Parasitic disease 0 161 0% 0 5 0%
Pathology 132 1432 9% 132 255 52%
Pregnancy complication 9 154 6% 9 18 50%
Respiratory tract disease 43 419 10% 43 87 49%
Signs and symptoms 266 1570 17% 266 511 52%
Skin disease 204 1156 18% 204 362 56%
Substance-related disorder 0 39 0% 0 5 0%
Urogenital disease 174 811 21% 174 273 64%
Viral disease 3 252 1% 3 16 19%
Wounds and injuries 3 245 1% 3 6 50%

The data in the current version of dSysMap is based on the contents of the following databases:

Database Version
UniprotKB 2017_01
Pfam 30.0
3did 2017_01
BINDTranslation 1.0
BioGRID 3.4.145
Database Version
DIP 05/02/2017
HPRD 041310
InnateDB 27/10/2015
IntAct 27/01/2017
PDB 2017_01